Mercado Central de Santiago

Puente Cal y Canto is a transfer station between the Line 2 and Line 3 of the Santiago Metro. Originally named Mapocho, it was renamed to Puente Cal y Canto shortly after its opening. This name is taken from the former bridge on the Mapocho River, whose remains were found during the construction of the station. The station's platforms walls have a decoration that resembles the architecture of the mentioned bridge. The Line 2 station was opened on 15 September 1987 as the northern terminus of the extension of the line from Los Héroes. On 8 September 2004 the line was extended to Cerro Blanco. The Line 3 station was opened on 22 January 2019 as part of the inaugural section of the line, from Los Libertadores to Fernando Castillo Velasco.This station has a ghost station belonging to the original project of the line 3. Nearby points of interest are the Estación Mapocho Culture Center and the Santiago Seafood Market.

The Santo Domingo Church (Spanish: Iglesia de Santo Domingo) is a Dominican church in the historical downtown of Santiago de Chile. It is located at the corner of Santo Domingo Street and 21 de Mayo Street.

The Cuartel General del Cuerpo de Bomberos de Santiago is a building located at the corner of Santo Domingo and Paseo Puente streets, in Santiago, Chile. It was opened in 1895 and serves as headquarters for the Firefighters Corps of Santiago. It was declared as a National Historic Monument in 1983.

The Posada del Corregidor is a building located at the corner of Corregidor Zañartu and Esmeralda streets, in downtown Santiago, Chile. It was declared as a National Historic Monument in 1970.

The Palacio de la Real Audiencia de Santiago (English: Royal Court Palace or Palace of the Boxes) is a building located in the north central village of the Plaza de Armas in Santiago, Chile. The building dates back to 1808 and houses, since 1982, the National History Museum of Chile. The building was built between 1804 and 1807 to serve as the home for the royal courts of justice. It was the work of Juan Goycolea, a pupil and disciple of the Italian-born Joaquin Toesca who had designed the nearby La Moneda Palace and the east facade of the Cathedral during the last two decades of the 18th century. The courts were there for two years until Chile's first government junta, in 1810, assembled to replace the Spanish governor. Eight years later the Chilean Declaration of Independence was solidified and the building served as the first meeting place for the new congress. It served as the seat of government until 1846, until President Manuel Bulnes moved to La Moneda Palace.

The Central Post Office Building (Spanish: Correo Central de Santiago) is a historic post office building on the northern edge of the Plaza de Armas, in Santiago, Chile. It is adjacent to the Palacio de la Real Audiencia de Santiago and is located on what was the land lot originally owned by Pedro de Valdivia and where he built his house. The site also was occupied by a building that served as Presidential Palace until 1846. Construction of the current building began in 1881 and was designed by Ricardo Brown. Its current appearance dates to 1908.It was designated a National Monument of Chile in 1976.

The Commune of Santiago is the central commune of the Santiago Province, located at the center of the Santiago Metropolitan Region in Chile's Central Zone. Locally, Santiago is usually abbreviated Stgo. It is also called as "Santiago Centro" (Downtown Santiago) in order to differentiate it from Greater Santiago, a larger entity which includes Santiago Commune along with other 36 communes.

La Vega Central, also known as the Feria Mapocho (Mapocho market), is a market located at the far south of Recoleta commune in Santiago de Chile, almost at the north bank of the Mapocho River. A wide variety of products are sold in its surrounds, principally fresh fruit and vegetables from the Chilean Central Valley. La Vega Central is also home to over 500 dairy, meat, goods and merchandise stores, and offers a variety of Chilean cuisine. Today, hundreds of thousands of people pass daily through La Vega's 60,000 square meters of stalls. La Vega Central has now achieved iconic status in Chile's capital. A long-time vendor at the market was quoted as saying, “Markets nowadays compete (for customers) by using marketing, but La Vega has never had to resort to this. It subsists on its own creation and that is its magic.”

The Santiago International Book Fair (Spanish: Feria Internacional del Libro de Santiago, FILSA) is an annual book fair held in Santiago, Chile, during October–December. It is organised by the Chilean Chamber for Books (Cámara Chilena del Libro).

Estación Mapocho is a former railway station that, since 1994, has been refitted as a cultural centre that hosts many kinds of events.

The Roman Catholic Archdiocese of Santiago de Chile (Latin: Archidioecesis Sancti Iacobi in Chile) is one of the five Latin Metropolitan sees of the Roman Catholic Church in Chile.

The gay protest in the Plaza de Armas in Santiago, which occurred on 22 April 1973, was the first LGBT demonstration in Chile, as well as one of the first in Latin America. The protestors were campaigning against police brutality, in particular against the beatings which they received.