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Genta (company)

1989 establishments in CaliforniaBiotechnology companies established in 1989Biotechnology companies of the United StatesCompanies based in Union County, New JerseyCompanies that filed for Chapter 11 bankruptcy in 2012
Pharmaceutical companies based in New JerseyPharmaceutical companies established in 1989

Genta Incorporated was a biopharmaceutical company started in La Jolla, California, which discovered and developed innovative drugs for the treatment of patients with cancer. Founded in 1989 by a highly skilled entrepreneur, the company focused on a novel technology known as antisense, which targets gene products that are associated with the onset and progression of serious diseases. At that time, only Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (formerly Isis Pharmaceuticals until December 2015) was conducting significant research with this technology. Antisense is a short span of oligonucleotides – modified DNA structures ranging from about 12-24 bases that selectively bind to specific RNA. The intent is to block expression of an aberrant protein that contributes to the disease of interest. Genta in-licensed three different antisense molecules that blocked Bcl-2, a fibroblast growth factor (FGF), and the gene c-myb, respectively.

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Genta (company)
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Connell Drive
07922
New Jersey, United States
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Berkeley Heights, New Jersey
Berkeley Heights, New Jersey

Berkeley Heights is a township in Union County, in the U.S. state of New Jersey. Located on a ridge in northern-central New Jersey, Berkeley Heights is a commuter town of New York City in the New York metropolitan area, nestled within the Raritan Valley region and also bordering both Morris and Somerset counties in the Passaic Valley region. As of the 2020 United States census, the township's population was 13,285, an increase of 102 (+0.8%) from the 2010 census count of 13,183, which in turn reflected a decline of 224 (−1.7%) from the 13,407 counted in the 2000 census.The township was originally incorporated as New Providence Township by the New Jersey Legislature on November 8, 1809, from portions of Springfield Township, while the area was still part of Essex County. New Providence Township became part of the newly formed Union County at its creation on March 19, 1857. Portions of the township were taken on March 23, 1869, to create Summit, and on March 14, 1899, to form the borough of New Providence. On November 6, 1951, the name of the township was changed to Berkeley Heights, based on the results of a referendum held that day. The township was named for John Berkeley, 1st Baron Berkeley of Stratton, one of the founders of the Province of New Jersey.The township has been ranked as one of the state's highest-income communities. Based on data from the American Community Survey for 2013–2017, township residents had a median household income of $147,614, ranked 15th in the state among municipalities with more than 10,000 residents, almost double the statewide median of $76,475.In Money magazine's 2013 Best Places to Live rankings, Berkeley Heights was ranked 6th in the nation, the highest among the three places in New Jersey included in the top 50 list. The magazine's 2007 list had the township ranked 45th out of a potential 2,800 places in the United States with populations above 7,500 and under 50,000.In its 2010 rankings of the "Best Places to Live", New Jersey Monthly magazine ranked Berkeley Heights as the 19th best place to live in New Jersey. In its 2008 rankings of the "Best Places To Live" New Jersey Monthly magazine ranked Berkeley Heights as the 59th best place to live in New Jersey.The township was listed as the fifth safest place in New Jersey as well as the ninth safest municipality in the nation according to a 2022 crime statistic compilation from Safewise.com.