M. Pico Building

The Lafayette County Courthouse, built in 1908, is an historic courthouse building located in Mayo, Florida. It was designed by Atlanta-based architect Edward Columbus Hosford in the Classical Revival style, who designed other courthouses in Florida and other states. It was built of Indiana limestone by the Mutual Construction Company of Louisville, Kentucky. Because there was no railroad into Lafayette County, the limestone and other materials were shipped by rail to O'Brien in Suwannee, County and then transported by wagon to Mayo, crossing the Suwannee River via Grant's Ferry north of Troy Springs. It is Lafayette County's third courthouse, the first at New Troy having burned down New Year's Eve 1892 and the second wooden structure in Mayo having been moved across the street to make way for a fireproof building. In 1989, the Lafayette County Courthouse was listed in A Guide to Florida's Historic Architecture, published by the University of Florida Press.

The Old Mayo Free Press Building, built in 1888 to house the Mayo Free Press newspaper, is an historic 20x40-foot wooden frame building located at 124 Fletcher Street, North (State Road 51) in Mayo, Florida. In 1989, it was listed in A Guide to Florida's Historic Architecture prepared by the Florida Association of the American Institute of Architects and published by the University of Florida Press.The Mayo Free Press later moved to a brick office building on the corner of San Pedro and Main street, which had been built in 1916 to house a drug store. The Mayo Free Press is now part of the Suwannee Democrat.In the 1980s the Old Mayo Free Press Building housed Granny's Country Store'. Today a sign on its front door proclaims that it is Le Chateau de Lafayette's House of Lydia. It is just south of the Old Lafayette County Courthouse which was moved to its present site around 1908 and now houses a bed and breakfast called Le Chateau de Lafayette.

The Old Lafayette County Courthouse, built 1893–1894, is an historic former courthouse building located on State Road 51 at 136 Fletcher Avenue, North, corner of Bloxham Street in Mayo, Florida, It was Lafayette County's second courthouse, the first at New Troy having burned down New Year's Eve 1892. It was built on the courthouse square in Mayo but was moved across the street to make way for a fireproof building, the present Lafayette County Courthouse. A two-story verandah was added on 3 sides after it was moved. In 1989, the Old Lafayette County Courthouse was listed in A Guide to Florida's Historic Architecture, published by the University of Florida Press. Today it is an inn called the Chateau.

The House of the Seven Gables built in the 1880s is an historic octagonal house located on the corner of Clark and Bloxham streets, North West, in Mayo, Florida, USA. After reading The House of the Seven Gables by Nathaniel Hawthorne, James Mitchell designed this house and had it built by Mack Koon. Seven of the eight sides are gabled, while the eighth side opens into a rear wing. As built, the house had three bedrooms and a parlor in the octagon section and cooking and dining areas in the wing. Dr. Charles Hailey of the University of Florida cites it as an example of the adaptation of "Florida 's small-town vernacular structures, 'minor monuments'", which are worthy of research. In 1989, it was listed in A Guide to Florida's Historic Architecture prepared by the Florida Association of the American Institute of Architects and published by the University of Florida Press. Recently, a storm nearly demolished the house. No plans are known for any restoration and the house, which had appeared to be beyond repair, has since been dismantled and the lot cleared.

Mayo, Florida is a town and the only municipality in Lafayette County, Florida, United States. It is the county seat of Lafayette County. The population was 1,055 at the 2020 census.

Alton is an unincorporated community in Lafayette County, Florida, United States. Its elevation is 82 feet (25 m), and it is located at 30°3′N 83°8′W (30.053,-83.138).

The Hal W. Adams Bridge, built in 1947, is a historic bridge that carries State Road 51 across the Suwannee River between Lafayette and Suwannee counties, Florida in the United States. Located 3 miles north of Mayo, it was the first suspension bridge built in Florida, and the only one to carry highway traffic. At its opening on July 4, 1947, it was named for Hal W. Adams of Mayo, former county judge of Lafayette County and then longtime circuit judge for the circuit encompassing Lafayette and Suwannee counties.In 1989, the Hal W. Adams Bridge was listed in A Guide to Florida's Historic Architecture, published by the University of Florida Press.

Lafayette County is a county located in the north central portion of the state of Florida. As of the 2020 census, the population was 8,226, making it the second-least populous county in Florida. The county seat is Mayo. Lafayette County is a prohibition or partially dry county, allowing retail sales of beer.

Wes Skiles Peacock Springs State Park is a 733-acre (297 ha) Florida State Park located on Peacock Springs Road, two miles (3 km) east of Luraville and on State Road 51, 16 miles (26 km) southwest of Live Oak, Florida. Activities include picnicking, swimming and diving, and wildlife viewing. Among the wildlife of the park are deer, bobcats, raccoon, squirrels, beaver and otters, as well as turkey, blue heron and barred owls. The park name commemorates the work of diver and explorer Wes Skiles. Prior to 2010 the park was known as Peacock Springs State Park. Amenities include a nature trail, six sinkholes, and Peacock and Bonnet Springs, with miles of underwater caves popular with cave divers. The two springs are tributaries of the Suwannee River. The park is open from 8:00 am till sundown year round.

Lafayette Blue Springs State Park is a Florida State Park, located on the west side of the Suwannee River, seven miles northwest of Mayo, off US 27. It contains one of the state's 33 first magnitude springs, with a daily discharge of up to 168 million gallons.

Branford is a town in Suwannee County, Florida, United States. The population was 712 at the 2010 census.

WMLO-LP (97.1 FM) is a radio station licensed to Live Oak, Florida, United States. The station is currently owned by Melody Christian Radio.