Franklin and Blackstone Squares

The South End District is a historic district encompassing a portion of the South End neighborhood of Boston, Massachusetts. It is bounded roughly by the Southwest Corridor Park on the northwest, the Massachusetts Turnpike to the north, Herald Street to the east, AlbanyStreet to the south east, and Massachusetts Avenue to the southwest. The area's principal development took place 1850–73, and resulted in a neighborhood of what were originally single-family brick or brownstone rowhouses, interspersed with retail and civic buildings, as well as six small parks. After the Panic of 1873 these properties were for the most part converted to multi-unit housing.The district was listed on the National Register of Historic Places in 1973. In 2014 it was expanded to include additional properties on the 200 block of Harrison Street.

Newton Street is a street-level bus station on the Washington Street branch of the MBTA Silver Line bus rapid transit service. It is located on Washington Street just south of East Newton Street and West Newton Street in the South End neighborhood of Boston, Massachusetts near the Boston University Medical Campus. The stop is served by the SL4 and SL5 Silver Line routes as well as several local MBTA bus routes. Like all Silver Line stops, Newton Street is accessible. Silver Line service on Washington Street began on July 20, 2002, replacing the route 49 bus. Service levels doubled on October 15, 2009, with the introduction of the SL4 route.

The Joshua Bates School is a historic school building at 731 Harrison Avenue in the South End neighborhood of Boston, Massachusetts. The 2+1⁄2-story Romanesque Revival brick building was designed by Arthur H. Vinal and built in 1884. It was named for financier and major benefactor of the Boston Public Library Joshua Bates. The school was closed in 1975 as a consequence of court-ordered desegregation actions. It was rehabilitated and adapted for use as artists' studios in 2003.The building was listed on the National Register of Historic Places in 2008.The original sea wall for the South End can still be seen on the Harrison Avenue side of its school yard. American poet James Hercules Sutton attended this school from 1947 to 1951.

The Lawrence Model Lodging Houses are historic apartment houses located at 79, 89, 99 and 109 East Canton Street in the South End of Boston, Massachusetts. Built in 1874, these 4+1⁄2-story brick buildings were designed by Boston architects, Charles K. Kirby and William F. Goodwin. Three of the four have a traditional Second Empire mansard roof, while the fourth has a brick-faced attic level. They were built with funds from industrialist and financier Abbott Lawrence, who left a $50,000 bequest to provide housing for the poor.On September 22, 1983, they were added to the National Register of Historic Places.

Elephant Walk is a French and Cambodian restaurant established in 1991 by Longteine "Nyep" de Monteiro.

The Boston University School of Medicine (BUSM) is one of the graduate schools of Boston University. Founded in 1848, the medical school was the first institution in the world to formally educate female physicians. Originally known as the New England Female Medical College, it was subsequently renamed BUSM in 1873. In 1864, it became the first medical school in the United States to award an M.D. degree to an African-American woman. BUSM is the only medical school located in the South End neighborhood of Boston, Massachusetts. Boston Medical Center, its primary teaching hospital, operates the largest 24-hour Level I trauma center in New England, and the largest network of regional community health centers.Boston University School of Medicine is the home of the Framingham Heart Study, from which all knowledge of cardiovascular disease risk factors were originally discovered. Notable alumni of the medical school include Marcia Angell, former editor-in-chief of the New England Journal of Medicine and the only woman to hold the position in the journal's almost 200-year history, as well as Louis Wade Sullivan, former Secretary of the US Department of Health and Human Services and founder of Morehouse School of Medicine. Boston University School of Medicine is ranked 29th on the 2019 list of Best Medical Schools in the Best Research category by the U.S. News & World Report.

Worcester Square station is a street-level bus station on the Washington Street branch of the MBTA Silver Line bus rapid transit service. It is located on Washington Street at Worcester Square in the South End neighborhood of Boston, Massachusetts near the Boston Medical Center. The stop is served by the SL4 and SL5 Silver Line routes as well as several local MBTA bus routes. Like all Silver Line stops, Worcester Square is accessible. Silver Line service on Washington Street began on July 20, 2002, replacing the route 49 bus. Worcester Square, which had been a stop for route 49, was not initially served by the Silver Line; it became a Silver Line stop on November 30, 2002. Shelters were added later.: 2.5  Service levels doubled on October 15, 2009, with the introduction of the SL4 route.

Massachusetts Homeopathic Hospital was a homeopathic institution in Boston, Massachusetts, at which the first successful kidney removal in New England was performed. Established by an act of the Massachusetts legislature in 1855, the hospital opened its doors in 1871 at a site in Jamaica Plain. In 1874 it moved into a newly built facility in the South End of Boston. Over the next 30 years its facilities in that area were expanded, and in 1908 it opened a satellite facility in Brighton for the treatment of contagious diseases. The hospital eventually abandoned homeopathic practices, and in 1929 became part of Massachusetts Memorial Hospitals. This was eventually merged into the Boston University Medical Center, now part of Boston Medical Center. The hospital's main building survives, and is known as the Talbot Building; it now houses the Boston University School of Public Health.

The Henry M. Goldman School of Dental Medicine is the dental school at Boston University. Its curriculum is based on the Applied Professional Experience (APEX) Program, which gives students practical experience at a dental practice as part of clinical training. The School has about 800 students in predoctoral and postdoctoral programs. The School can trace its origins to 1958 when the Boston University Medical School started a Department of Stomatology to provide postdoctoral education in dentistry. At that time, the institution was the only one in the country devoted solely to specialty education in dentistry. In 1963, it became Boston University School of Graduate Dentistry under the leadership of Dean Henry M. Goldman. In 1970, the School moved to 100 East Newton Street. In 1972, the School included a predoctoral program leading to a DMD degree. In September 2021, the School completed a three-year expansion/renovation project at an approximate $115 million cost.In 1996, the School was renamed the “Boston University Henry M. Goldman School of Dental Medicine” In 2008, Dr. Jeffrey W. Hutter was named Dean. He retired on March 31, 2021.In November 2021, Dr. Cataldo Leone was named Dean.

The Cathedral of the Holy Cross is the cathedral of the Roman Catholic Archdiocese of Boston and is the largest Roman Catholic church in New England.When construction was finished, the cathedral rivaled both Old South Church and Trinity Church in grandeur. The cathedral is located in the city's South End neighborhood, at 1400 Washington St. Although the South End was initially developed for Boston's emerging Anglo-Saxon Protestant middle class, the neighborhood transitioned to new immigrants, especially Irish, as middle class owners moved to the new Back Bay neighborhood. The cathedral functions both as a cathedral and as a parish. The Cathedral Parish consists of large English- and Spanish-speaking congregations, drawn largely from the local area, and also includes three Archdiocese-wide congregations: the Ge'ez Rite practiced by Ethiopian, Eritrean, and Egyptian Catholics; the German Apostolate; and the Tridentine Mass Catholic community. The first of these congregations moved to the cathedral from the nearby Holy Trinity Catholic Church in 1994, the other two in 2008.

The Boston City Hospital (1864–1996), in Boston, Massachusetts, was a public hospital, located in the South End. It was "intended for the use and comfort of poor patients, to whom medical care will be provided at the expense of the city, and ... to provide accommodations and medical treatment to others, who do not wish to be regarded as dependent on public charity." In 1996, it merged with the Boston University Medical Center Hospital to form the Boston Medical Center.This building is currently under study for Boston Landmark status by the Boston Landmarks Commission.

Boston Medical Center (BMC) is a non-profit 514-bed academic medical center in Boston, Massachusetts. It is the largest safety-net hospital and Level I trauma center in New England.BMC employs 1,466 physicians—including 711 residents and fellows—and 1,849 nurses. Kathleen E. Walsh has been the president and chief executive officer since 2010.