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The New Swan Theater is an outdoor, portable theater that is assembled and disassembled each summer as part of New Swan Shakespeare Festival, the annual Shakespeare festival at the University of California, Irvine. It is a reduced-size replica of Shakespeare's Globe Theatre.

The School of Physical Sciences is an academic unit of the University of California, Irvine (UCI) that conducts academic research and teaching in the field of physical sciences. It offers both pre-professional training and general education in the departments of chemistry, earth system science, mathematics, and physics and astronomy. The school enrolls 1,400 undergraduate and graduate students and is one of the top schools in the nation in the number of degrees it confers in the area of physical sciences. It also offers specializations such as biochemistry, statistics, math for economics, applied and computational mathematics, astrophysics, applied physics, biomedical physics, and education. In 1995, the school gained international prominence when Frank Sherwood Rowland, a professor in chemistry and Frederick Reines, a professor in physics, won the Nobel Prize in their respective fields. It was the first time two people won the prize in the same year in two different fields at the same public university.

The University of California, Irvine (UCI or UC Irvine) is a public land-grant research university in Irvine, California. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and professional degrees, and roughly 30,000 undergraduates and 6,000 graduate students are enrolled at UCI as of Fall 2019. The university is classified among "R1: Doctoral Universities – Very high research activity", and had $436.6 million in research and development expenditures in 2018. UCI became a member of the Association of American Universities in 1996. The university was rated as one of the "Public Ivies” in 1985 and 2001 surveys comparing publicly funded universities the authors claimed provide an education comparable to the Ivy League.The university also administers the UC Irvine Medical Center, a large teaching hospital in Orange, and its affiliated health sciences system; the University of California, Irvine, Arboretum; and a portion of the University of California Natural Reserve System. UC Irvine set up the first Earth System Science Department in the United States.UC Irvine was one of three new UC campuses established in the 1960s to accommodate growing enrollments across the UC system. A site in Orange County was identified in 1959, and in the following year the Irvine Company sold the University of California 1,000 acres (400 ha) of land for one dollar to establish the new campus. President Lyndon B. Johnson dedicated the campus in 1964, a fact commemorated with the delivery of a commencement speech by President Barack Obama fifty years later.As of January 2022, there have been 8 Nobel Prize laureates, 7 Pulitzer Prize winners, 6 MacArthur "Genius Grant" recipients, 37 Guggenheim Fellows, and 1 Turing Award winner affiliated with the university as alumni, faculty or researchers.The UC Irvine Anteaters currently compete in the NCAA Division I as members of the Big West Conference. During the early years of the school's existence, the teams played at the NCAA Division II level. The Anteaters have won 28 national championships in nine different team sports, 64 Anteaters have won individual national championships, and 53 Anteaters have competed in the Olympics, winning 27 Olympic medals.

The campus of the University of California, Irvine is known for its concentric layout with academic and service buildings arrayed around a central park, and for its Brutalist architecture.

The School of Biological Sciences (formerly the Francisco J. Ayala School of Biological Sciences) is one of the academic units of the University of California, Irvine (UCI). The school is divided into four departments: developmental and cell biology, ecology and evolutionary biology, molecular biology and biochemistry, and neurobiology and behavior. With over 3,700 students it is in the top four largest schools in the university. It is consistently ranked in the top one hundred in U.S. News & World Report’s yearly list of best graduate schools.

The Donald Bren School of Information and Computer Sciences, also known colloquially as UCI's School of ICS or simply the Bren School, is an academic unit of University of California, Irvine (UCI), and the only dedicated school of computer science in the University of California system. Consisting of nearly three thousand students, faculty, and staff, the school maintains three buildings in the South-East section of UCI's undergraduate campus, and maintains student body and research affiliations throughout UCI.The school of ICS consists of three departments: Computer Science, Informatics, and Statistics. The combined groupings focus the school around the fields of computing and processing of information. The departments confer eight undergraduate, eleven masters, and seven doctoral degrees in total, with some degree programs cooperating with affiliated schools.

The Henry Samueli School of Engineering (HSSoE) is the academic unit of the University of California, Irvine (UC Irvine) that oversees academic research and teaching in disciplines of the field of engineering. Established when the campus opened in 1965, the school consists of five departments, each of which is involved in academic research in its specific field, as well as several interdisciplinary fields. The school confers Bachelor of Science, Master of Science, and Doctor of Philosophy degrees. According to the UC Irvine academic catalogue, HSSoE research areas include: biochemical and bioreactor engineering, earthquake engineering, water resources, transportation, parallel and distributed computer systems, intelligent systems and neural networks, image and signal processing, opto-electronic devices and materials, high-frequency devices and systems, integrated micro and nanoscale systems, fuel cell technology, fluid mechanics, combustion and jet propulsion, materials processing, robotics, and modern control theory.In 2000, the school, along with its counterpart at the University of California, Los Angeles (UCLA), were renamed in honor of Henry Samueli, co-founder of Irvine-based Broadcom Corporation, for his 1999 donations of $20 million and $30 million to the schools of engineering at UC Irvine and UCLA, respectively.The most recent permanent Dean of the HSSoE was Gregory Washington, who held the position from August 1, 2011 until July 1, 2020 when he resigned in order to accept appointment as President of George Mason University. Michael Green currently serves as interim dean, and Magnus Egerstedt will take over as dean in July of 2021.

The Center for the Neurobiology of Learning and Memory (CNLM) is a research center established in 1983 in the School of Biological Sciences at the University of California, Irvine that studies memory and learning. Center faculty reported the first known case of hyperthymesia; they have also done research on false memory syndrome. James McGaugh was the founding director, and noted memory expert Elizabeth Loftus is a research fellow of the center.Dr. Michael A. Yassa, professor of neurobiology and behavior and James L. McGaugh Endowed Chair, has served as center director since 2016.

The School of Social Ecology (SSE) is a school of the University of California, Irvine (UCI) that studies social ecology. As of 2015, the School enrolls nearly 3,000 students and is the third largest school at UCI by student population. Students in the social ecology program at UCI undergo a multidisciplinary program that examines real-world social and environmental issues and that involves the students in off-campus internships as well as on-campus courses. SSE offers undergraduate and graduate degrees, including bachelor's, professional master's, and Ph.D.s. The school has three departments: Criminology, Law and Society; Psychological Science (prior to Fall 2019 known as Psychology and Social Behavior); and Urban Planning and Public Policy. It is also home to approximately 70 faculty, 2,500 undergraduate students, 300 graduate students, and over 20,000 alumni; it offers five undergraduate degrees and eight graduate degrees, including two professional degrees.

The Irvine Barclay Theatre, often referred to as The Barclay, is a 755-seat performing arts theater in Irvine, California, located on the campus of the University of California, Irvine. Jointly owned by the city and university, it opened in 1990 and has hosted various musicians, bands, plays, and guest speakers. The Barclay Theatre was designed by San Francisco-based architecture firm Wurster, Bernardi and Emmons.

The Claire Trevor School of the Arts (CTSA, Claire Trevor) is an academic unit at the University of California, Irvine, focused on the performing and visual arts. The four departments housed in the school are for art, dance, drama, and music. CTSA has undergraduate programs, masters programs, and a doctoral program in drama conducted jointly with UC San Diego.