The 2016 WEC 6 Hours of Spa-Francorchamps, formally the WEC 6 Heures de Spa-Francorchamps, was a six-hour endurance sports car racing event held for Le Mans Prototype and Le Mans Grand Touring Endurance cars at the Circuit de Spa-Francorchamps, Stavelot, Belgium on 5–7 May 2016. Spa-Francorchamps served as the second race of the 2016 FIA World Endurance Championship, and was the fifth running of the event as part of the championship. A total of 56,000 people attended the race.
The No. 1 Porsche of Timo Bernhard, Mark Webber and Brendon Hartley started from pole position and held the race's overall lead until the No. 5 Toyota TS050 Hybrid of Sébastien Buemi, Anthony Davidson and Kazuki Nakajima gained it after the first pit stop phase after electing not to change tyres. He held it until smoke billowed from his engine, causing him to return to his garage for repairs. Audi's No. 8 car of Oliver Jarvis, Lucas di Grassi and Loïc Duval inherited the lead which they maintained for the remainder of the race to secure the team's first victory of the season. Porsche's first car, driven by the eventual Drivers' Champions, Romain Dumas, Neel Jani and Marc Lieb finished second, and the No. 13 Rebellion Racing car of Dominik Kraihamer, Alexandre Imperatori and Mathéo Tuscher came in third. It was Jarvis's and di Grassi's first victory in the FIA World Endurance Championship.
The Le Mans Prototype 2 (LMP2) category was won by the Signatech Alpine driven by Nicolas Lapierre, Gustavo Menezes and Stéphane Richelmi. Lapierre took the lead in the closing stages of the race after passing No. 31 Extreme Speed Motorsports driver Pipo Derani which earned Menezes and Richelmi their first LMP2 class victories in the World Endurance Championship. Sam Bird and Davide Rigon in the No. 71 AF Corse Ferrari took the victory in the Le Mans Grand Tourer Endurance Professional (LMGTE Pro) class with a one-lap advantage over second-placed No. 67 Ford Chip Ganassi Team drivers Andy Priaulx, Marino Franchitti and Harry Tincknell. The Le Mans Grand Tourer Endurance Amateur (LMGTE Am) category was led for most of the final hour by the No. 98 Aston Martin of Pedro Lamy, Paul Dalla Lana and Mathias Lauda and held it to clinch victory in the class, ahead of the No. 83 AF Corse Ferrari driven by François Perrodo, Emmanuel Collard and Rui Águas.
The result meant Marc Lieb, Neel Jani and Romain Dumas maintained their Drivers' Championship lead with 43 points, 15 ahead of third-place finishers Kraihamer, Imperatori and Tuscher, and a further point in front of race winners Duval, di Grassi and Jarvis. Nick Heidfeld, Nico Prost and Nelson Piquet Jr. retained fourth place and Kamui Kobayashi, Mike Conway and Stéphane Sarrazin rounded out the top five. Porsche increased its lead in the Manufacturers' Championship on 56 points, 13 in front of their nearest rival Toyota in second, and a further two ahead of Audi with seven races left in the season.