DePew Lodge No. 823, Free and Accepted Masons

Bruce—Briggs Brick Block is a historic rowhouse block located at Lancaster in Erie County, New York. It is a mid-19th century brick structure unique in Western New York, which incorporates both Greek Revival and Italianate style decorative details. The rowhouses were built for George Bruce, one of the early settlers of Lancaster.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

Liebler—Rohl Gasoline Station is a historic filling station located at Lancaster in Erie County, New York. It is the Village of Lancaster's sole example of historic 20th century roadside commercial architecture. It is in the Tudor Revival style of architecture. It operated as a gasoline station into the 1960s; currently it operates as a seasonal ice cream shop, known as Frosty's.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

John P. Sommers House is a historic home located at Lancaster in Erie County, New York. It was built in 1906, and is a 2+1⁄2-story, wood-frame Queen Anne style dwelling. It has a hipped roof and center projecting gable. It features a prominent two-story, five-sided corner tower and has a single-story porch across the front facade.It was added to the National Register of Historic Places in 2012.

The Clark–Lester House is a historic home located at Lancaster in Erie County, New York. It is a Queen Anne style dwelling constructed about 1891. It was home to noted psychology professor Olive Lester, who lived here for most of her adult life until May 1996. She was the first woman chair of any of the departments at the University at Buffalo. It is now operated as a bed and breakfast. It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

Miller—Mackey House is a historic home located at Lancaster in Erie County, New York. It is a locally distinctive example of the Colonial Revival style of architecture built in 1905 for Dr. John G. Miller. In 1957, the Depew Lancaster Boys' Club purchased the property and since that time has been used as a recreational and social facility for the area's young people.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

Dr. John J. Nowak House is a historic home located at Lancaster in Erie County, New York. It is a locally significant and distinct example of the Spanish Revival style built for Dr. John J. Nowak in 1930. Several additions were built throughout the years and it is now used as a nursing home.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

Broadway Historic District is a national historic district located at Lancaster in Erie County, New York. The district encompasses 85 contributing resources in the village of Lancaster. The district includes a variety of commercial, residential, religious and institutional buildings built between about 1831 and 1940. It includes notable examples of Greek Revival, Italianate, Queen Anne, Colonial Revival, and Bungalow / American Craftsman style architecture. Located in the district are the separately listed Lancaster Municipal Building (1940), Miller-Mackey House (c. 1900), Clark-Lester House (ca. 1891), Bruce-Briggs Brick Block (c. 1855), Lancaster Masonic Lodge Hall (1916-1919), Liebler-Rohl Gasoline Station (c. 1935), Dr. John J. Nowak House (ca. 1930), Zuidema-Idsardi House (c. 1870), Herman B. VanPeyma House (ca. 1890), and John Richardson House (c. 1840). Other notable buildings include the Seeger Store Building (c. 1910), Brost Building (c. 1935) designed by Edward Brodhead Green, Maute House (c. 1880), Depew Lancaster Moose Lodge No. 1605 (c. 1880) B.P.O.E. Lodge/Potter's Hall (c. 1924), and Lancaster Presbyterian Church (1832-1833).It was listed on the National Register of Historic Places in 2015.

Lancaster Municipal Building is a historic municipal building in Lancaster, Erie County, New York. It is also known as Lancaster Village Hall, and was built in 1940.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

Zuidema-Idsardi House is a historic home located at Lancaster in Erie County, New York. It is a locally significant and distinct example of the vernacular interpretation of Italianate style, incorporating elements of Eastlake movement ornamentation. It was built for John H. Zuidema, a local Dutch businessman, circa 1876.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

US Post Office—Lancaster is a historic post office building located at Lancaster in Erie County, New York. It was designed and built 1938–1939, and is one of a number of post offices in New York State designed by the Office of the Supervising Architect of the Treasury Department, Louis A. Simon. The building is in the Colonial Revival style. The interior features a mural by Arthur Getz painted in 1940 and titled "Early Commerce in the Erie Canal Region."It was listed on the National Register of Historic Places in 1989.

Herman B. VanPeyma House is a historic home located at Lancaster in Erie County, New York. It is a locally significant distinct example of the eclectic architecture featuring the Queen Anne style, built circa 1890. It was built for Herman Boetkhout VanPeyma, an early Dutch immigrant to the Town of Lancaster.It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.

Central Avenue Historic District is a national historic district located at Lancaster in Erie County, New York. The district encompasses 17 contributing buildings in the central business district of the village of Lancaster. The district includes a variety of residential, commercial, and government buildings built between about 1860 and 1940. It includes notable examples of Italianate and Colonial Revival style architecture. Notable buildings include the Lancaster Town Hall and Opera House (c. 1894, 1976-1978), Former Post Office (c. 1905), Cushing Block (c. 1896), and Potter-Eaton House (c. 1895, moved 1940).It was listed on the National Register of Historic Places in 2014.