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The Swift Packing Plant was a division of Swift and Company located at South 27th and Q Streets in South Omaha, Nebraska. The plant was opened in 1887 and closed in 1969. It covered approximately eight square blocks and consisted of several brick and stone buildings, and was located in proximity to the Omaha Stockyards. It was located on the South Omaha Terminal Railway, and next to the Omaha Stockyards, making Swift one of the "Big Four" packing companies in Omaha.

The Wilson Packing Plant was a division of the Wilson and Company meatpacking company located near South 27th and Y Streets in South Omaha, Nebraska. Founded in the 1890s, it closed in 1976. It occupied the area bounded by Washington Street, South 27th Street, W Street and South 30th Street. Located on the South Omaha Terminal Railway and next to the Omaha Stockyards, Wilson was regarded as one of the "Big Four" packing companies in Omaha.

The Armour Packing Plant was a division of Armour and Company located at South 29th and Q Streets in South Omaha, Nebraska. The plant opened in 1897 and closed in 1968. The plant included several buildings, including a remarkable red brick administrative building, and a large, tall wall which surrounded the facility. It was located on the South Omaha Terminal Railway, and next to the Omaha Stockyards, making Armour one of the "Big Four" packing companies in Omaha.

The O Street Viaduct was located in the South Omaha, Nebraska. Built to accommodate O Street traversing over the Union Pacific tracks, the overpass was constructed in 1885 by interests associated with the Omaha Stockyards. It was included on the Bridges in Nebraska Multiple Property Submission on June 29, 1992. The bridge was demolished in 2001 as part of the redevelopment of the stockyards.

Upland Park is a public park located at 3014 Jefferson Street in South Omaha, Nebraska. The park and surrounding neighborhood were opened in 1913. Upland Park has two tennis courts, two soccer fields, walking paths, and a small playground at the park, along with a "sprayground," which is a small water park. The sprayground replaced a swimming pool located at the park for several decades during a park-wide renovation in 1999. The spraygrounds are attributed in the 412 percent increase in park attendance in the year following its opening, drawing 7,500 additional users to the park annually. The park has been an important location for low-income and immigrant youth to play soccer, and according to the Omaha World-Herald, it was integral to the Omaha South High School's soccer team's success.Because of its proximity to the former ASARCO site in Omaha, the park has been identified as being contaminated with lead.

The South Omaha City Hall is part of the South Omaha Main Street Historic District located at 5002 South 24th Street in the South Omaha neighborhood of Omaha, Nebraska. It was designed by notable local architect John Latenser, Sr.

The Livestock Exchange Building in Omaha, Nebraska, was built in 1926 at 4920 South 30 Street in South Omaha. It was designed as the centerpiece of the Union Stockyards by architect George Prinz and built by Peter Kiewit and Sons in the Romanesque revival and Northern Italian Renaissance Revival styles. In 1999 it was designated an Omaha Landmark and listed on the National Register of Historic Places. The Union Stockyards were closed in 1999, and the Livestock Exchange Building underwent an extensive renovation over the next several years.

Packer's National Bank Building is located at 4939 South 24th Street in the South Omaha Main Street Historic District in south Omaha, Nebraska. It was built in 1907. In 1984, it was designated an Omaha Landmark and, in 1985, it was listed on the National Register of Historic Places.

The Union Stockyards of Omaha, Nebraska, were founded in 1883 in South Omaha by the Union Stock Yards Company of Omaha. A fierce rival of Chicago's Union Stock Yards, the Omaha Union Stockyards were third in the United States for production by 1890. In 1947 they were second to Chicago in the world. Omaha overtook Chicago as the nation's largest livestock market and meat packing industry center in 1955, a title which it held onto until 1971. The 116-year-old institution closed in 1999. The Livestock Exchange Building was listed on the National Register of Historic Places in 1999.

The South Omaha Main Street Historic District is located along South 24th Street between M and O Streets in South Omaha, Nebraska. It was added to the National Register of Historic Places in 1989. Home to dozens of historically important buildings, including the Packer's National Bank Building, the historic district includes 129 acres (0.52 km2) and more than 32 buildings.

El Museo Latino is a museum featuring Latino and Hispanic art and history that is located at 4701 South 25th Street in South Omaha, Nebraska. Established in 1993, by Magdalena García, it is the first Latino art and history museum and cultural center in the Midwest.

The Cudahy Packing Plant ( CUD-ə-hey) was a division of the Cudahy Packing Company located at South 36th and O Streets in South Omaha, Nebraska. The plant was opened in 1885 and closed in 1967. The plant included more than 20 buildings that were one to six stories tall, covering five square blocks. It was located on the South Omaha Terminal Railway, and next to the Omaha Stockyards, making Cudahy one of the "Big Four" packing companies in Omaha.