George Rogers Clark Memorial Bridge

Mayor Andrew Broaddus is a lifesaving station built by the United States Life-Saving Service located in Louisville, Kentucky, off the corner of River Road and Fourth Street. She is named in honor of Andrew Broaddus (1900-1972), a former mayor of Louisville (1953-1957). Her historic purpose was to protect travelers on the Ohio River from the Falls of the Ohio, with rescue crews for those who fell victim to the rapids. Louisville was the first place where a lifesaving station was placed in western waters. The first lifestation in Louisville was in 1881, with Mayor Andrew Broaddus as the third. A National Historic Landmark, she is the only surviving floating lifesaving station of the US Life-Saving Service.

Belle of Louisville is a steamboat owned and operated by the city of Louisville, Kentucky, and moored at its downtown wharf next to the Riverfront Plaza/Belvedere during its annual operational period. The steamboat claims itself the "most widely traveled river steamboat in American history." Belle of Louisville's offices are aboard Mayor Andrew Broaddus, and also appears on the list of National Historic Landmarks.

The KFC Yum! Center is a multi-purpose indoor arena in Downtown Louisville, Kentucky, United States. It is named after the KFC restaurant chain and Yum! Brands, the parent company of KFC. Adjacent to the Ohio River waterfront, it is located on Main Street between 2nd and 3rd Streets and opened on October 10, 2010. The arena is part of a $450 million project that includes a 975-car parking structure and floodwall. The Louisville Cardinals men's and women's basketball teams from the University of Louisville are the primary tenants of the arena complex. The U of L women's volleyball team began using the arena as a part-time home in 2011, and made the arena its main home in 2012. With 22,090 seats for basketball, it is the largest arena in the United States by seating capacity designed primarily for basketball, and the second-largest used for college basketball, behind the JMA Wireless Dome at Syracuse University, a venue built to house football and lacrosse in addition to basketball. The arena's current attendance record for a sporting event is 22,815, set March 9, 2013, against Notre Dame (men's basketball). The current attendance record for any event is 23,085, set March 9, 2019, when Metallica played their WorldWired Tour.From April to May 2021, it was home to the Louisville Xtreme of the Indoor Football League, but they were voted out of the league after five games.

Louisville Waterfront Park is both a non-profit organization and an 85-acre (340,000 m2) public park adjacent to the downtown area of Louisville, Kentucky and the Ohio River. Specifically, it is adjacent to Louisville's wharf and Riverfront Plaza/Belvedere, which are situated to the west of the park. Once a wasteland of scrap yards and abandoned industrial buildings, Waterfront Park is now a vibrant green space that welcomes over 2.2 million visitors each year. Located in the park is the Big Four Bridge which connects the city of Louisville with the City of Jeffersonville, Indiana. Waterfront Park is home to some of Louisville's most exciting celebrations, such as the Fourth of July at Waterfront Park, Forecastle Festival, WFPK Waterfront Wednesdays and Thunder Over Louisville. In 2013 the park won the Rudy Bruner Award for Urban Excellence a national design award that seeks to identify and honor places that address economic and social concerns in urban design.

Whiskey Row in Louisville, Kentucky refers an area along Main Street, close to the Ohio River, which was home to the bourbon industry.

Louisville (varying pronunciations: US: LOO-ə-vəl, LOO-ee-vil, locally LUUV-əl) is the most populous city in the Commonwealth of Kentucky, sixth-most populous city in the Southeast, and the 27th-most-populous city in the United States. By land area, it is the country's 24th-largest city, although by population density, it is the 265th most dense city. Louisville is the historical county seat and, since 2003, the nominal seat of Jefferson County, on the Indiana border. Named after King Louis XVI of France, Louisville was founded in 1778 by George Rogers Clark, making it one of the oldest cities west of the Appalachians. With the nearby Falls of the Ohio as the only major obstruction to river traffic between the upper Ohio River and the Gulf of Mexico, the settlement first grew as a portage site. It was the founding city of the Louisville and Nashville Railroad, which grew into a 6,000-mile (9,700 km) system across 13 states. Today, the city is known as the home of boxer Muhammad Ali, the Kentucky Derby, Kentucky Fried Chicken, the University of Louisville and its Cardinals, Louisville Slugger baseball bats, and three of Kentucky's six Fortune 500 companies: Humana, Kindred Healthcare, and Yum! Brands. Muhammad Ali International Airport, Louisville's main commercial airport, hosts UPS's worldwide hub. Since 2003, Louisville's borders have been the same as those of Jefferson County, after a city-county merger. The official name of this consolidated city-county government is the Louisville/Jefferson County Metro Government, abbreviated to Louisville Metro. Despite the merger and renaming, the term "Jefferson County" continues to be used in some contexts in reference to Louisville Metro, particularly including the incorporated cities outside the "balance" which make up Louisville proper. The city's total consolidated population as of the 2020 census was 782,969. However, the balance total of 633,045 excludes other incorporated places and semiautonomous towns within the county and is the population listed in most sources and national rankings. The Louisville-Jefferson County, KY-IN Metropolitan Statistical Area (MSA) includes Louisville-Jefferson County and 12 surrounding counties, seven in Kentucky and five in Southern Indiana. As of 2019, the MSA had a population of 1,395,634, the 43rd largest in the nation.

Louisville National Medical College (1888–1912), was a historically Black medical school in the United States, located in Louisville, Kentucky. At the time it was founded, there were four other medical schools in Louisville. The first graduate of the medical school was a woman.

The John F. Kennedy Memorial Bridge is a six-lane, single-deck cantilever bridge that carries southbound Interstate 65 across the Ohio River, connecting Louisville, Kentucky and Jeffersonville, Indiana. The main span is 700 feet (213 m) (two spans) and the bridge has a total length of 2,498 feet (761 m). The span carries six southbound lanes. It is named after U.S. President John F. Kennedy.

The Abraham Lincoln Bridge is a six-lane, single-deck cable-stayed bridge carrying northbound Interstate 65 across the Ohio River, connecting Louisville, Kentucky, and Jeffersonville, Indiana. The main span is 700 feet (213 m) (two spans) and the bridge has a total length of 2,100 feet (640 m). It is named after U.S. President Abraham Lincoln, who was born in Kentucky and grew up in Southern Indiana.

The Galt House Hotel is a 25-story, 1,300-room hotel in Louisville, Kentucky, established in 1972. It is named for a nearby historic hotel erected in 1835 and demolished in 1921. The Galt House is the city's only hotel on the Ohio River.

Corn Island, formerly Dunmore's Island, was an island in the Ohio River at head of the Falls of the Ohio, just north of Louisville, Kentucky. Estimates of the size of Corn Island, now submerged, vary with time, as it gradually was eroded and became submerged. A 1780 survey listed its size at 43 acres (170,000 m2). It then extended from what is now Louisville's Fourth to Fourteenth Streets. The first settlement that later became Louisville on the mainland was established on the island in 1778 by George Rogers Clark.

Actors Theatre of Louisville is a non-profit performing arts theater located in downtown Louisville, Kentucky. Actors Theatre was founded in 1964 following the merging of two local companies, Actors, Inc. and Theatre Louisville, operated by Louisville natives Ewel Cornett and Richard Block. Designated as the "State Theater of Kentucky" in 1974, the theatre has been called one of America's most consistently innovative professional theatre companies, with an annual attendance of 150,000. The theatre presents almost 400 performances annually, including classics and contemporary work through the Brown-Forman Series, holiday plays, a series of free theatrical events produced by the Professional Training Company, and the Humana Festival of New American Plays. In addition, the theatre provides arts experiences to students across the region through its education department and supports a pre-professional resident training program, the Professional Training Company.The theatre has been the recipient of a Tony Award for Distinguished Achievement, the James N. Vaughan Memorial Award for Exceptional Achievement and Contribution to the Development of Professional Theatre, and the Margo Jones Award for the Encouragement of New Plays. The theater has toured to 29 cities and 15 countries. Currently, there are more than 50 published books of plays and criticism from the theater in circulation—including anthologies of Humana Festival plays, volumes of ten-minute plays and monologues, and essays, scripts and lectures from the Brown-Forman Classics in Context Festival. Numerous plays first produced at the theatre have also been published as individual acting editions.