Joseph C. O'Mahoney Federal Center

The United States District Court for the District of Wyoming (in case citations, D. Wyo.) is the federal district court whose jurisdiction comprises the state of Wyoming and those portions of Yellowstone National Park situated in Montana and Idaho; it is the only federal court district that includes portions of more than one state, creating a possible "Zone of Death" where it would be difficult to prosecute crimes. The court has locations in Cheyenne and Casper. Appeals from this court are heard by the United States Court of Appeals for the Tenth Circuit (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit). The United States Attorney's Office for the District of Wyoming represents the United States in civil and criminal litigation in the court. As of June 29, 2022 the acting United States attorney is Nicholas Vassallo.

The Federal Office Building-Cheyenne, at 308 W. 21st St. in Cheyenne, Wyoming, is a Classical Revival-style building built in 1932. It was listed on the National Register of Historic Places in 2000.It is a four-story masonry building 127 by 50 feet (39 m × 15 m) in plan, upon a full basement. It was built to a three-story height, with capacity to add four more stories. The fourth floor was added in 1937.

St. Mary's Cathedral is the cathedral and parish church in the Diocese of Cheyenne located in Cheyenne, Wyoming, United States. It was listed on the National Register of Historic Places in 1974.

The Lulu McCormick Junior High School at 2001 Capitol Ave. in Cheyenne, Wyoming was built in 1929. It was a work of Frederick Hutchinson Porter. It has also been known as Emerson Building. It was listed on the National Register of Historic Places in 2005.

The Charles L. Beatty House, also known as the Kendrick Building, on Capitol Avenue in Cheyenne, Wyoming, was built in 1916. It was listed on the National Register of Historic Places in 1990.It is an American Foursquare house designed by architect William Robert Dubois. The listing included two contributing buildings.It is located across from the Wyoming State Capitol. The building was the home of the Wyoming Arts Council for two decades, until January 2015, when WAC moved to the Barrett Building, co-locating with the Wyoming State Museum.

The Wyoming State Museum is a state-run museum established in 1895 in Cheyenne, Wyoming. It is the official state repository for material concerning Wyoming history and cultural heritage.Permanent exhibit themes include coal, flora and fauna, fossils, Wyoming settlement, Native American culture and history, the National Park Service in Wyoming, and other Wyoming-related issues. The museum also hosts a variety of temporary exhibits and provides traveling exhibits to cultural institutions in Wyoming and surrounding states.

The City and County Building, also known as the City-County Building, at 19th St. and Carey Ave. in Cheyenne, Wyoming, was built during 1917–1919. It was designed by architect William Dubois in Classical Revival style. It was listed on the National Register of Historic Places in 1978. It was deemed significant for association with the Laramie County government and the City of Cheyenne governments' development, as well as "for the quality of its craftsmanship and detailing." It combined city hall and courthouse functions and originally held 14 county and six city offices, besides courts.

The Wyoming State Capitol is the state capitol and seat of government of the U.S. state of Wyoming. Built between 1886 and 1890, the capitol is located in Cheyenne and contains the chambers of the Wyoming State Legislature as well as the office of the Governor of Wyoming. It was designated a U.S. National Historic Landmark in 1987. The Capitol underwent an extensive three-year renovation and reopened to the public on July 10, 2019.

Cheyenne ( shy-AN or shy-EN) is the capital and most populous city of the U.S. state of Wyoming, with 65,132 residents, per the 2020 US Census. It is the principal city of the Cheyenne metropolitan statistical area which encompasses all of Laramie County and had 100,512 residents as of the 2020 census. Local residents named the town for the Cheyenne Native American people in 1867 when it was founded in the Dakota Territory.Cheyenne is the northern terminus of the extensive Southern Rocky Mountain Front, which extends southward to Albuquerque, New Mexico, and includes the fast-growing Front Range Urban Corridor. Cheyenne is situated on Crow Creek and Dry Creek.

The Masonic Temple in Cheyenne, Wyoming, is a building dating from 1901. It was listed on the National Register of Historic Places in 1984.It is a 3-story buff brick-veneer building with a concrete foundation. The building burned in 1903 and was rebuilt with very few changes. An addition was added in 1929.

The Wyoming House of Representatives is the lower house of the Wyoming State Legislature. There are 60 Representatives in the House, representing an equal number of single-member constituent districts across the state, each with a population of at least 9,000. The House convenes at the Wyoming State Capitol in Cheyenne. Members of the House serve two year terms without term limits. Term limits were declared unconstitutional by the Wyoming Supreme Court in 2004, overturning a decade-old law that had restricted Representatives to six terms (twelve years).The current Speaker of the House is Eric Barlow.

The Wyoming Senate is the upper house of the Wyoming State Legislature. There are 30 Senators in the Senate, representing an equal number of constituencies across Wyoming, each with a population of at least 17,000. The Senate meets at the Wyoming State Capitol in Cheyenne. Members of the Senate serve four year terms without term limits. Term limits were declared unconstitutional by the Wyoming Supreme Court in 2004, overturning a decade-old law that had restricted Senators to three terms (twelve years). Like other upper houses of state and territorial legislatures and the federal U.S. Senate, the Wyoming Senate can confirm or reject gubernatorial appointments to the state cabinet, commissions, boards, or justices to the Wyoming Supreme Court.