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The United Charities Building, also known as United Charities Building Complex, is at 105 East 22nd Street or 287 Park Avenue South, in the Gramercy Park neighborhood of Manhattan, New York City, near the border of the Flatiron District. It was built in 1893 by John Stewart Kennedy, a wealthy banker, for the Charity Organization Society. It was designated a National Historic Landmark in 1991 for the role the Charity Organization Society played in promoting progressive social welfare policies, including the development of academic disciplines in that area.

121 East 22nd (also 122 East 23rd Street) is a building in the Gramercy Park neighborhood of Manhattan in New York City, developed by American company Toll Brothers. It is the first building in New York City designed by Rem Koolhaas's architectural firm OMA.

Church Missions House (also known as 281 Park Avenue South) is a historic building at Park Avenue South and East 22nd Street in the Gramercy Park neighborhood of Manhattan in New York City, in an area once known as "Charity Row". The building was designed by Robert W. Gibson and Edward J. Neville Stent, with a steel structure and medieval-inspired facade. The design was inspired by the town halls of Haarlem and medieval Amsterdam. Church Missions House is so named because it was the headquarters of the Episcopal Church's Domestic and Foreign Missionary Society for much of the 20th century. The facade is made of granite at the ground story and Indiana Limestone on the other stories. The facade's composition is based on the arrangement of the superstructure, which is arranged as a grid of rectangles. The main entrance is through a porch at the center of the Park Avenue facade. Inside, the building contains at least 33,600 square feet (3,120 m2) of space. As of December 2019, all six floors of the building are occupied by Fotografiska New York, an offshoot of the Swedish photography museum Fotografiska. The Domestic and Foreign Missionary Society sought to develop a dedicated headquarters for much of the 19th century. The Church Missions House building was built between 1892 and 1894. The building was sold in 1963 to the Federation of Protestant Welfare Agencies (FPWA). The New York City Landmarks Preservation Commission designated Church Missions House as a landmark in 1979 and it was added to the National Register of Historic Places in 1982. The FPWA moved out of the building in 2015 and Fotografiska New York opened there in 2019.

Fotografiska New York is a branch of the Swedish photography museum Fotografiska in Gramercy Park, Manhattan, New York City. The museum's home is the Church Missions House, a six-story, 45,000-square-foot (4,200 m2) Renaissance Revival landmark. It opened in December 2019.In addition to galleries, the museum was home to Veronika, a restaurant operated by Stephen Starr. Open for a few months before it paused due to the coronavirus pandemic, Veronika at Fotografiska Museum, according to TimeOut was a "high profile, gilded restaurant" that "never truly got going again." It permanently closed on September 1, 2021.

Calvary-St. George's Parish is an Episcopal parish in Manhattan, New York City. According to the church website, its mission is to "divide the word of truth between Law and Gospel, so that the people in the city of New York and beyond might know and confess where they end and God begins." The current Priest-in-Charge is Jake Smith, who came to the parish and was ordained as a presbyter in the fall of 2006. The other priests are Jim Munroe, and Nancy Hanna. Kamel Boutros, a former singer with Metropolitan Opera, is music director. In 2020, it reported 966 members, average attendance of 264, and $823,362 in plate and pledge income. Calvary-St George's was the birthplace of Alcoholics Anonymous. It also served as the launch point for Let My People Go, a non-profit organization that teaches churches how to fight human trafficking, and sponsors Out Not Down, an LGBT youth homelessness prevention program. A soup kitchen ministry serves meals to approximately 125 people on Thursdays at noon. The parish also hosts a children's Christmas pageant open to "[w]hoever shows up at church," according to Wall Street Journal.After a May 1, 2016 fire burned neighboring church Serbian Orthodox Cathedral of St. Sava, members of that parish temporarily used the St George's sanctuary to gather. St George's also hosts St. Ann’s Church for the Deaf, the first church for the Deaf in the United States, and Sea Dog Theater, a non-profit off-Broadway theater troupe.During the early days of New York's 2020 coronavirus lockdown, New York Post reported on the church's bells, which played "Amazing Grace" and other hymns four times a day. Calvary-St George's connection to Harry Thacker Burleigh, one of the first African-American composers to incorporate spirituality into music, was subject of a February 2021 PIX11 Black history moment.

The 23rd Street station is a local station on the IRT Lexington Avenue Line of the New York City Subway. Located at the intersection of Park Avenue South and 23rd Street in Gramercy Park and Flatiron District, Manhattan, it is served by 6 trains at all times, <6> trains during weekdays in the peak direction, and 4 trains during late night hours. The 23rd Street station was constructed for the Interborough Rapid Transit Company (IRT) as part of the city's first subway line, which was approved in 1900. Construction of the line segment that includes the 23rd Street station started on September 12 of the same year. The station opened on October 27, 1904, as one of the original 28 stations of the New York City Subway. The station's platforms were lengthened in the late 1940s. The 23rd Street station contains two side platforms and four tracks; express trains use the inner two tracks to bypass the station. The station was built with tile and mosaic decorations, which are continued along the platform extensions. The platforms contain exits to 22nd Street to the south and 23rd Street to the north. The platforms are not connected to each other within fare control. The station contains elevators from the street, which make it compliant with the Americans with Disabilities Act of 1990.

The Manhattan Trade School for Girls was a New York City public high school founded in 1902 by Mary Schenck Woolman, and was the first vocational school for female students established in the United States. It was established by philanthropic reformers to provide training for young women to work in trades such as garment factory work. It was originally located on West 14th Street, but was moved to East 23rd Street in 1906–1907. To accommodate growing enrollment, a new building was constructed and designed by C. B. J. Snyder in 1915 at 127 East 22nd Street. The building now houses The School of the Future, a New York City public middle school and high school.

School of the Future is a public secondary school located at 127 East 22nd Street at Lexington Avenue, in the Gramercy Park neighborhood of the borough of Manhattan in New York City. It serves grades 6 through 12 as a part of the New York City Department of Education, and accepts students from around the entire city. School of the Future, a small school, was founded in 1990 with funding by Apple Inc. with an admissions process dependent on student application. The school is a member of the Coalition of Essential Schools, a league of schools dedicated to small class sizes and student-centered learning. In 2005, School of the Future was chosen as a national mentor school of CES as part of a Gates Foundation-funded effort to improve schools nationwide.

Gramercy Park Hotel is a luxury hotel located at 2 Lexington Avenue, in the Gramercy Park neighborhood of Manhattan, New York City, adjacent to the park of the same name. It is known for its rich history.

300 Park Avenue South (previously the Mills & Gibb Building and currently also known as The Creative Arts Center) is a building on the northwest corner of East 22nd Street in the Flatiron District/Gramercy Park neighborhoods of Manhattan, New York City.

Calvary Church is an Episcopal church located at 277 Park Avenue South on the corner of East 21st Street in the Gramercy Park neighborhood of Manhattan, New York City, on the border of the Flatiron District. It was designed by James Renwick Jr., the architect who designed St. Patrick's Cathedral and Grace Church, and was completed in 1848. The church complex is located within the Gramercy Park Historic District and Extension. It is one of the two sanctuaries of the Calvary-St. George's Parish.

The Lyceum Theatre was a theatre in New York City located on Fourth Avenue (now Park Avenue South) between 23rd and 24th Streets in Manhattan. It was built in 1885 and operated until 1902, when it was torn down to make way for the Metropolitan Life Insurance Company Tower. It was replaced by a new Lyceum Theatre on 45th Street. For most of its existence, the theatre was home to Daniel Frohman's Lyceum Theatre Stock Company, which presented many important plays and actors of the day.