James Mitchell Rogers House

Conrad-Starbuck House is a historic home located at Winston-Salem, Forsyth County, North Carolina. It was built in 1884, and is a 2+1⁄2-story, three-bay, double pile Italianate style brick dwelling. It has a number of rear additions. The central projecting bay once had a three-story tower, but the top level was removed between 1912 and 1917.It was listed on the National Register of Historic Places in 1990. The property was purchased in 2019 by Spear Properties Group, with plans to renovate the house and surrounding land to fit historic roots. The house now serves as office suites for downtown Winston-Salem.

BB&T Financial Center is a 340-foot (100 m) postmodern green glass and steel skyscraper at 200 West 2nd Street and is the 2nd tallest building in Winston-Salem, Forsyth County, North Carolina, United States with 271,445 square feet (25,218.1 m2) of space. It was completed in 1987 and has 21 floors. It served as the headquarters of BB&T from the merger of BB&T and Southern National Bank in 1995. The 19th floor has The Piedmont Club, with 13,232 square feet (1,229.3 m2) feet.

Hylehurst, also known as the John W. Fries House, is a historic home located at Winston-Salem, Forsyth County, North Carolina, United States. It was designed by Henry Hudson Holly and built in 1884. The house is a three-story, Queen Anne style dwelling. It features projecting gable ends with timbering and scalloped shingles and a wraparound verandah. It was built for John W. Fries, a prominent Winston-Salem industrialist, whose father built the Arista Cotton Mill Complex.The house was listed on the National Register of Historic Places in 1983.

William Allen Blair House is a historic home located at Winston-Salem, Forsyth County, North Carolina. It was built in 1901, and is a two-story, Colonial Revival style frame dwelling. It has a one-story, wrap-around front porch and Porte-cochère. The house features a high hipped roof with gabled dormers and central facade gable with a projecting second story bay and a Palladian window.It was listed on the National Register of Historic Places in 1985.

Shamrock Mills, also known as Hanes Hosiery Mill #1, is a historic textile mill building located at Winston-Salem, Forsyth County, North Carolina. It was built in 1911, and is a one-story brick building with daylight basement. It is six bays deep and extends in seven sections with a rhythmic saw-tooth roof and six-foot skylights. An addition was built in 1925. It was the first building used by the Hanes Hosiery Company. The mill closed in 1926, and the building subsequently housed a Cadillac dealership. The building houses the Sawtooth School for Visual Art. It was listed on the National Register of Historic Places in 1978.

100 North Main Street, also known as Wells Fargo Center, is a postmodern, 460-foot (140 m), 34-floor office skyscraper in Winston-Salem, North Carolina, United States. Originally named Wachovia Center, the building served as the corporate headquarters of Wachovia bank from 1995, the year of the tower's construction, to 2001, the year the corporation merged with First Union and moved its headquarters to Charlotte, North Carolina. It is the tallest building in the Piedmont Triad region and was the tallest in the Carolinas outside Charlotte until 2008, when RBC Plaza (now PNC Plaza) was completed in Raleigh. The building was designed by Petronas Towers architect César Pelli and features Moravian architectural themes, which are widely found in Winston-Salem. Notable aspects include the Moravian arch, which was used in the dome's design, and the Moravian star, which was used on the lobby's mosaics. Pelli said the tower design resembled a rosebud about to bloom. It is sheathed in Olympia white granite and is the only granite-domed skyscraper in the world. The granite comes from a single quarry in Sardinia. The dome rises 59 ft (18 m) and houses mechanical equipment. The gardens around the site were designed by Cesar Pelli's wife Diana Balmori, a landscape architect. Atlanta based developer Taylor & Mathis, managed the development.

Winston-Salem Southbound Railway Freight Warehouse and Office is a historic railway freight warehouse and office building located at Winston-Salem, Forsyth County, North Carolina. It was built in 1913, and is a two-story, brick railroad building with a shallow gable roof and Italianate-style design elements. It measures 40 feet by 224 feet. The building served until 1985 as headquarters for the Winston-Salem Southbound Railway. In 1990, the building was sympathetically renovated for office use.It was listed on the National Register of Historic Places in 1991.

Spruce Street YMCA is a historic YMCA building located at Winston-Salem, Forsyth County, North Carolina. It was built in 1927, and is a four-story, brick and limestone building in the Classical Revival style. The front facade features pilasters with Corinthian order capitals and two entrances with arched openings. The building house a YMCA until 1976.It was listed on the National Register of Historic Places in 1984.

Salem Town Hall is a historic town hall located at Winston-Salem, Forsyth County, North Carolina, United States. It was designed by architect Willard C. Northup and built in 1912. It is a two-story brick building with stone, cement and wood trim. It features a three-story corner bell tower and has Italianate and local Moravian design elements. The building housed the Salem Town offices until it consolidated with the town of Winston in 1913, then moved to the newly built Winston-Salem City Hall in 1926. The building continued to be used as a fire station until the mid 1970s. It was subsequently renovated into offices.It was listed on the National Register of Historic Places in 1983.

Arista Cotton Mill Complex, also known as Salem Cotton Manufacturing Company and Arista Cotton Mill (Fries Mill Complex) and Lentz Transfer & Storage Co., is a historic cotton mill complex located at Winston-Salem, Forsyth County, North Carolina. The complex includes two buildings: a brick building built in 1836 by part of the Moravian congregation of Salem and the original home of the Salem Cotton Manufacturing Company, and the other is the original Arista Mill, built in 1880 by F. and H. Fries Cotton Arista Mills. The 1836 Salem Cotton Mill is a three-story, brick building with a monitor roof. The 1880 mill is a three-story brick building, 14 bays long, with bracketed eaves with timber supports. A two-story roughly triangular brick building was added about 1900. The 1836 building has been converted to a hotel known as The Historic Brookstown Inn. It was listed on the National Register of Historic Places in 1977.

Winston-Salem City Hall is a historic city hall located at Winston-Salem, Forsyth County, North Carolina. It was designed by the architectural firm Northup and O'Brien and built in 1926. It is a three-story, U-shaped Renaissance Revival building. It is a brick building with a first floor of rusticated stone. It has a flat roof with a limestone cornice and balustrade with shaped balusters. The Salem town offices were housed in the Salem Town Hall until consolidation in 1913. The building was renovated in 2000.It was listed on the National Register of Historic Places in 2001.

Kaleideum in Winston-Salem, North Carolina was created from the July 2016 merger of Children's Museum of Winston-Salem and SciWorks, the Science Center and Environmental Park of Forsyth County. Currently, the museum operates two locations — Kaleideum Downtown (formerly The Children's Museum of Winston-Salem) and Kaleideum North (formerly SciWorks).