Bishop's Palace, Galveston

The East End Historic District encompasses a large 19th-century residential area in eastern Galveston, Texas. The area is roughly bounded by Broadway to the south, Market St to the north, 19th St to the west, and 9th street to the east. The area has one of the best-preserved and largest concentrations of 19th-century residential architecture in Texas. It was developed mainly at a time when Galveston was the state's preeminent port. The historic district, designated locally in 1970, was placed on the National Register of Historic Places in 1975 and declared a National Historic Landmark in 1976.

The Isaac Heffron House is a two-story building located at 1509 Postoffice Street (Avenue E) in the East End Historic District of Galveston, Texas. The house was built by Isaac Heffron, a prominent Galveston contractor in the Victorian period and during the city's recovery from the 1900 Galveston Hurricane. Later, the house was the residence of T.J. Holbrook, a Texas state senator from 1922 to 1939.

The Mathilda Wehmeyer House and German-American Kindergarten School is a two-story building located at 1616 Winnie St. (Avenue G) in Galveston, Texas. Built in 1887, the building housed a school operated by German immigrant Mathilda Wehmeyer between 1891 and 1898.

The George Washington Grover House is a two-story house located at 1520 Market (Avenue D) in the East End Historic District of Galveston, Texas. Built in 1859, the house is one of the oldest brick residences in the city.

The Sonnentheil House is a historic house located at 1826 Sealy Ave. in Galveston, Texas. After the original Sonnenthiel home was destroyed in the Great Fire of 1885, Jacob Sonnentheil bought a double lot on the northeast corner of 19th and Sealy and built this house. The house was described as having been "planned from the inside out" meaning the interior spaces were planned prior to the exterior design.No architect claimed it at the time of construction, but it is suspected to be designed by Nicholas J. Clayton, because of stylistic elements common to Clayton's work. The Texas Historic Landmark inscription states: Built in 1886-87 for German native Jacob Sonnentheil (d. 1908), this home probably was designed by prominent Galveston architect Nicholas J. Clayton. Sonnentheil served with the Confederacy during the Civil War and operated a wholesale dry goods store on The Strand in Galveston. The Sonnentheil house displays influences of Eastlake, Gothic, and Italianate architectural styling. Outstanding features include the finely-crafted double galleryLee Trentham, a wealthy Houston chemical engineer and businessman purchased the house in 1976 and spent $275,000 restoring it. The Sonnentheil Home was owned by Arthur Louis Schechter from 1987 until 1999.

First Presbyterian Church is a historic church building at 1903 Church Street in Galveston, Texas. The Presbyterian congregation was organized in 1840 with the assistance of missionaries from the United States, and it met in a wooden church building from 1843 to 1872, the first church building in Galveston. The current Romanesque building was constructed in 1872 and is considered one of the best examples of Norman architecture in the region. It was designed by Nicholas J. Clayton, a prominent early Texas architect. The church was added to the National Register of Historic Places in 1979. Currently, the congregation is affiliated with the Presbyterian Church (U.S.A.), the Synod of the Sun, and of New Covenant Presbytery.

The Galveston National Laboratory (GNL) in Galveston, Texas, United States, is a high security National Biocontainment Laboratory housing several Biosafety level 4 research laboratories. The lab is run by the University of Texas Medical Branch (UTMB) for exotic disease diagnosis and research. The GNL is one of the 15 biosecurity level 4 facilities in the United States and the largest one in the world located on an academic campus.

The Shriners Children's Texas is a 30-bed non-profit pediatric burn hospital, research, and teaching center located on the campus of the University of Texas Medical Branch in Galveston, Texas, US. Part of a 22-hospital system, it is one of the three Shriner's Hospitals that specialize exclusively in burn care and consists of an intensive care unit with 15 acute beds and a reconstruction and plastic surgery unit with 15 reconstruction beds along with three operating rooms and beds for orthopedic and spine care. The hospital is verified as a burn center by the American Burn Association and accredited by the Joint Commission on Accreditation of Healthcare Organizations. In 2012, the hospital joined the Texas Medical Center as its 50th member institution.

The University of Texas Medical Branch (UTMB) is a public academic health science center in Galveston, Texas, United States. It is part of the University of Texas System. UTMB includes the oldest medical school in Texas, and has about 11,000 employees. In February 2019, it received an endowment of $560 million.Established in 1891 as the University of Texas Medical Department, UTMB has grown from one building, 23 students and 13 faculty members to more than 70 buildings, more than 2,500 students and more than 1,000 faculty. It has five schools (Medicine, Nursing, Health Professions, Public and Population Health, and Graduate Biomedical Sciences), three institutes for advanced study, a comprehensive medical library, four on-site hospitals (including an affiliated Shriners Hospital for Children), a network of clinics that provide primary and specialized medical care and numerous research facilities. UTMB's primary missions are health sciences education, medical research (it is home to the Galveston National Laboratory) and health care services. Its emergency department at John Sealy Hospital is certified as a Level I Trauma Center and serves as the lead trauma facility for a nine-county region in Southeast Texas; it is one of only three Level I Trauma centers serving all ages in Southeast Texas.In fiscal year 2012, UTMB received 20 percent of its $1.5 billion budget from the State of Texas to help support its teaching mission, hospital operation and Level 1 Trauma Center; UTMB generates the rest of its budget through its research endeavors, clinical services and philanthropy. It provides a significant amount of charity care (almost $96 million in 2012), and treats complex cases such as transplants and burns.In 2003 UTMB received funding to construct a $150 million Galveston National Biocontainment Laboratory on its campus, one of the few non-military facilities of this level. It houses several Biosafety Level 4 research laboratories, where studies on highly infectious materials can be carried out safely. It has schools of medicine, nursing, allied health professions, and a graduate school of biomedical sciences, as well as an institute for medical humanities. UTMB also has a major contract with the Texas Department of Criminal Justice to provide medical care to inmates at all TDC sites in the eastern and southern portions of Texas. UTMB also has similar contracts with local governments needing inmate medical care. On March 10, 2022, UTMB announced that the School of Medicine would be renamed to the John Sealy School of Medicine in honor of the over $1 billion donated to the university and medical school by the Sealy family and the Sealy & Smith Foundation over the last century.

John Sealy Hospital is a hospital that is a part of the University of Texas Medical Branch complex in Galveston, Texas, United States.

The United States Customs House and Court House, also known as Old Galveston Customhouse, in Galveston, Texas, is a former home of custom house, post office, and court facilities for the United States District Court for the Eastern District of Texas, and later for the United States District Court for the Southern District of Texas. Completed in 1861, the structure is now leased by the General Services Administration to the Galveston Historical Foundation. The courthouse function was replaced in 1937 by the Galveston United States Post Office and Courthouse.

The Galveston County Courthouse is the county government's courthouse building in Galveston County, Texas. Several buildings have been constructed for and used as the courthouse over the years.