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The Original Ninfa's on Navigation is a popular Mexican restaurant located at 2704 Navigation Boulevard in Houston, Texas. The restaurant serves both Tex-Mex and Mexican cuisine. The Original Ninfa's was started by Ninfa Rodríguez Laurenzo, a Mexican-American woman, in a tortilla factory. Ninfa Laurenzo became a full-time restaurateur and the tortilla factory closed. Mama Ninfa is widely credited with popularizing the fajita among Houstonians. Dai Huynh of the Houston Chronicle said that the Ninfa's locations opened after the first two restaurants "failed to attract the following of earlier restaurants." Tom Laurenzo said that the Laurenzo family never became very wealthy while it controlled the Ninfa's restaurants. He said "Everything was put back into the business." When the Laurenzo family controlled the restaurant chain, it was managed by Ninfa's Inc., which became a subsidiary of the Laurenzo-controlled holding company RioStar Corp.

Our Lady of Guadalupe Catholic School (Spanish: Escuela de Nuestra Señora de Guadalupe) is a Roman Catholic K-8 school in the Second Ward in the East End, Houston, Texas. It is the parish school of the Our Lady of Guadalupe Catholic Church of the Roman Catholic Archdiocese of Galveston-Houston. Our Lady of Guadalupe Catholic School is the oldest continuously operating Catholic elementary school in the City of Houston. As of 2010 the school's parish is one of the poorest Catholic parishes in Greater Houston.

Our Lady of Guadalupe Catholic Church (Spanish: Iglesia Nuestra Señora de Guadalupe) is a Roman Catholic church located in the Second Ward in the East End, Houston, Texas. It is a part of the Roman Catholic Archdiocese of Galveston-Houston. The church, first constructed in 1911, was the first Mexican-American church in Houston. It was the first religious institution in the City of Houston to offer religious services in the Spanish language. The church opened one of the first schools for Mexican-American children and it operates programs that provided food and shelter for needy individuals. As of 2012 the church serves 3,500 families. Many of its masses are held in Spanish. The surrounding neighborhood is predominately Hispanic. As of 2010 OLG is one of the poorest Catholic parishes in Greater Houston. It includes the Our Lady of Guadalupe School, the oldest Catholic elementary school in Houston.

Talento Bilingüe de Houston (TBH, "Bilingual Theater of Houston") is a bilingual English-Spanish theater in the Second Ward in the East End, Houston, Texas. It is located at the intersection of Jensen Road and Navigation Drive, adjacent to Guadalupe Park, and two city blocks from Downtown Houston.

East Early College High School (EECHS) is a secondary charter school at 220 N. Milby Street in Houston, Texas, United States with a ZIP code of 77003. The school is operated by the Houston Independent School District in association with the Houston Community College System Southeast Campus and the Bill and Melinda Gates Foundation. The school is on the HCC Southeast Campus. EECHS is a 2018 recipient of the U.S. Department of Education's Blue Ribbon School of Excellence award.

East End Houston, managed by the East End District (EED), is a district in eastern Houston, Texas, United States, located between the eastern edge of downtown to the Port of Houston and South to Hobby Airport. The District is home to Houston's early history and industry and is the site of Harrisburg, the seat of government for the Republic of Texas in 1836. East End Houston consists of many different ethnic groups, including Hispanic, Asian, White, and African American. Latinos make up more than half of the 100,512 residents, The area includes two of Houston's oldest Hispanic neighborhoods, Magnolia Park and Second Ward.

Street to Kitchen is a restaurant in Houston, in the U.S. state of Texas. Established in 2020, during the COVID-19 pandemic, the restaurant earned chef Benchawan Jabthong Painter a James Beard Foundation Award for Best Chef: Texas in 2023.The restaurant moved in November of 2023 to a larger space.

Coffee Plant/Second Ward is a light rail station in Houston, Texas on the METRORail system. It is served by the Green Line and is located on Harrisburg Boulevard between York and Hutcheson streets. The station is named for the Second Ward neighborhood as well as a former Maxwell House coffee manufacturing plant. In 2006, Maxwell House sold the plant to Maximus Coffee Group which currently operates the plant under the Atlantic Coffee Solutions brand.Coffee Plant/Second Ward station opened on May 23, 2015, as part of the Green Line's first phase.

Second Ward (also known as Segundo Barrio, Spanish for "second neighborhood", or Segundo in short; historically Das Zweiter in German) is a historical political district ward in the East End community in Houston, Texas. It was one of the four original wards of the city in the nineteenth century. The community known as the Second Ward today is roughly bounded by Buffalo Bayou to the north, Lockwood Avenue to the east, and railroad tracks to the south and west, although the City of Houston's "Super Neighborhood" program includes a section east of Lockwood. The Second Ward, which initially had a significant German American population, today has mainly Mexican American residents. Many Mexican-Americans moved into the area following World War II and the subsequent white flight from the area. The northern end of the community is largely industrial, leading to massive warehouse complexes along the Bayou. There are also many industrial buildings, some of which have found new life as lofts, on the western edge of the neighborhood nearest to Downtown and Minute Maid Park. Many buildings in the community were constructed in the 1920s and bear the art deco style. While perceived as rundown and neglected in the 1800. to 2020, recent years have seen major civic improvements including new street lights and pavement, as well as the beginnings of gentrification as professionals and others move from both the far-flung suburbs and other, more expensive Inner Loop neighborhoods. Residents of all ages frequent the Ripley House Community Center. The Second Ward is in the early stages of gentrification, drawing new residents with its proximity to downtown.

East Downtown Houston (EaDo) is a district in Houston, Texas, United States. The East Downtown Management District (EDMD), manages the area with offices headquartered at START Houston, a co-working space 1121 Delano Street. The community is located east of Downtown Houston and north of Interstate 45 (Gulf Freeway). It is between the George R. Brown Convention Center and the East End district.The Old Chinatown, an area within East Downtown bounded by Interstate 69/U.S. Route 59, Preston Street, St. Joseph Parkway, and Dowling Street (now Emancipation Avenue), is the older of the two Houston Chinatowns. The East Downtown Chinatown is not the same as the Chinatown in southwestern Houston.

EaDo/Stadium is a light rail station in Houston, Texas on the METRORail system. It is served by the Green and Purple lines. The station is named for the East Downtown Houston (EaDo) neighborhood as well as PNC Stadium, which the station serves. PNC Stadium is home to the Houston Dynamo of Major League Soccer and Houston Dash of the National Women's Soccer League. EaDo/Stadium station opened on May 23, 2015, as part of the first phase of the Green Line.

The National Biscuit Company Building, located at 15 North Chenevert in Houston, Texas, was built for Nabisco in 1910, and listed on the National Register of Historic Places on February 20, 1998. The structure was converted to apartments and is now known as City View Lofts.