General Electric Building

The Lexington Avenue/51st Street station is a New York City Subway station complex on the IRT Lexington Avenue Line and IND Queens Boulevard Line. The station is located on Lexington Avenue and stretches from 51st Street to 53rd Street in Midtown Manhattan. It is served by the 6 and E trains at all times, and by M trains during weekdays. In addition, <6> trains stop here during weekdays in the peak direction, and 4 trains stop here during late nights. The complex comprises two stations: 51st Street on the Lexington Avenue Line and Lexington Avenue–53rd Street station (originally Lexington—Third Avenues) on the Queens Boulevard Line. Originally two separate stations, these were connected in 1988 via a transfer passage, which was opened with the construction of 599 Lexington Avenue. Approximately 50,000 riders transfer between the Lexington Avenue and Queens Boulevard Lines each weekday.In 2019, the station complex had an annual ridership of 18,957,465, making it the tenth-busiest in the system.

345 Park Avenue is a 634-foot (193 m) skyscraper in the Midtown Manhattan neighborhood of New York City. It occupies an entire city block bounded by Park Avenue, Lexington Avenue, 51st Street, and 52nd Street. Completed in 1969, with 44 floors, the building was designed by Emery Roth & Sons. It is near the Racquet and Tennis Club and Park Avenue Plaza to the northeast; the Seagram Building to the north; 599 Lexington Avenue to the northeast; and St. Bartholomew's Episcopal Church and the General Electric Building to the south. It is built on the site of the Hotel Ambassador, which had opened in 1921. It was sold to Sheraton Hotels in 1958 and renamed the Sheraton-East. It was demolished in 1966. Exteriors of 345 Park Avenue were used as the headquarters of CSC and Continental Corp. in the Aaron Sorkin series Sports Night from 1998 to 2000.

The Benjamin Royal Sonesta New York (formerly the Beverly Hotel and Benjamin Hotel) is a hotel at 125 East 50th Street, at the northeast corner with Lexington Avenue, in the Midtown Manhattan neighborhood of New York City. The 29-story hotel was designed by Emery Roth in the neo-Romanesque style and contains 209 rooms. The Benjamin, one of several hotels developed around Grand Central Terminal as part of Terminal City, is a New York City designated landmark. The hotel building's facade consists largely of limestone and brick. The building contains light courts facing east, as well as setbacks to comply with the 1916 Zoning Resolution, which taper to an octagonal tower at the top of the hotel. The limestone base is two stories high and contains storefronts and a main entrance on 50th Street. The upper stories are generally clad with brick and contain architectural terracotta and cast stone ornamentation. The hotel contained a double-height lobby, which was originally designed in the Spanish style, as well as a restaurant. The upper stories were divided into 177 apartments of one to four rooms each, although these were rearranged into 209 guestrooms in 1999. Moses Ginsberg developed the Beverly as an apartment hotel, which opened in October 1927. Ginsberg continued to operate the Beverly until 1951, when he sold it to real-estate investor Irving Maidman. International Hotels Inc. bought the Beverly in 1959 and renovated it. After a series of sales in the late 20th century, Manhattan East Suite Hotels (later Denihan Hospitality Group) acquired the Beverly in 1997 and renovated it over the next two years, renaming the hotel the Benjamin. The hotel was again renovated between 2010 and 2013, and Sonesta International Hotels acquired the Benjamin in 2021.

The Four Seasons was a New American cuisine restaurant in New York City. Established in 1959, it was located at 99 East 52nd Street, in the Seagram Building in Midtown Manhattan, until 2016. From 2018 to its closure in 2019, it was located at 42 East 49th Street in Midtown Manhattan. The restaurant was owned by the Bronfman family, Alex von Bidder, and Julian Niccolini at the time of its closure. The Four Seasons is associated with a number of milestone firsts in the hospitality industry. The Four Seasons is credited with introducing the idea of seasonally-changing menus to America, and was the first destination restaurant to print its menus in English. The restaurant was widely praised, winning the James Beard Award many times. The restaurant's interior, which was designed by the building's architects Ludwig Mies van der Rohe and Philip Johnson, remained almost unchanged since construction in 1959. Art inside the restaurant included paintings by Mark Rothko; a permanent mural by James Rosenquist; a major Richard Lippold sculpture; a curtain designed by Pablo Picasso; and temporary exhibitions that included works by Joan Miró, Frank Stella, Ronnie Landfield, Robert Indiana, and Richard Anuszkiewicz. The restaurant's interior was designated by the New York City Landmarks Preservation Commission as an interior landmark in 1989.

St. Bartholomew's Church, commonly called St. Bart's, is a historic Episcopal parish founded in January 1835, and located on the east side of Park Avenue between 50th and 51st Street in Midtown Manhattan, in New York City. In 2018, the church celebrated the centennial of its first service in its Park Avenue home.In 2020, it reported 2,196 members, average attendance of 386, and $2,791,353 in plate and pledge income. On October 31, 2016, the St. Bartholomew's Church and Community House complex was designated a National Historic Landmark, for its significance as an important example of early 20th-century ecclesiastical architecture designed by Bertram Goodhue.

Belmont Plaza Hotel was a hotel in New York City at 49th Street and 541-555 Lexington Avenue, across the street from the Waldorf Astoria.It was purchased by real estate developer and hotelier Alfred Kaskel in the fall of 1945. The Glass Hat Club at the Belmont was a popular supper club, where Dean Martin and Jerry Lewis were performing when they met in August 1944. In August 1964, the land on which the hotel was situated had been sold to the Massachusetts Mutual Life Insurance Company for $4.4 million, but that they leased it back immediately to Kaskel and his Belplaza Corporation.

DoubleTree by Hilton Hotel Metropolitan New York City (originally the Summit Hotel; formerly the Loews New York Hotel and Metropolitan Hotel) is a hotel in the East Midtown neighborhood of Manhattan in New York City, United States. Designed by architect Morris Lapidus, in association with the firm of Harle & Liebman, the hotel is at 569 Lexington Avenue, at the southeast corner with 51st Street. The DoubleTree Metropolitan Hotel is owned by Hawkins Way Capital and contains 800 rooms. The hotel building, designed in the Miami Modern style, is a New York City designated landmark. The hotel is 20 stories tall and stretches from west to east, with an "S"-shaped massing bent at two places. The hotel has a facade made of marble, turquoise glazed brick, and dark-green tile. There are storefronts along both 51st Street and Lexington Avenue. Above the DoubleTree's main entrance on Lexington Avenue is a vertical sign, consisting of ovals that originally spelled out the hotel's name. The lowest stories contained the lobby, three Latin American-themed dining areas, various shops, and meeting rooms. When the Summit Hotel opened, it contained 800 guest rooms, including 200 rooms with balconies on the upper stories. The site was previously occupied by the Loew's Lexington Theatre, which was built in the 1910s. Loew's Theatres announced plans to replace the theater in early 1960, and a groundbreaking ceremony for the hotel took place on June 21, 1960. The Summit Hotel opened on August 1, 1961, and was Manhattan's first new hotel for short-term tenants in thirty years. When the Summit opened, its facade and interior were almost universally criticized, though the building's shape had a mixed reception. Over the years, the hotel has been renovated several times. The Summit was renamed the Loews New York Hotel in 1991 and became the Metropolitan Hotel in 2000. Loew's sold the hotel in 2003 to a joint venture, which rebranded it as part of the DoubleTree chain in 2005. The hotel was sold to RLJ Lodging Trust in 2011, and it was resold yet again in 2022 to Hawkins Way Capital. As of 2022, the hotel was closed indefinitely due to the COVID-19 pandemic in New York City.

The Seagram Building is a skyscraper at 375 Park Avenue, between 52nd and 53rd Streets, in the Midtown Manhattan neighborhood of New York City. Designed by Ludwig Mies van der Rohe, Philip Johnson, Ely Jacques Kahn, and Robert Allan Jacobs, the building measures 515 feet (157 m) tall with 38 stories and a public plaza. The International Style building, completed in 1958, initially served as the headquarters of the Seagram Company, a Canadian distiller. Phyllis Lambert, daughter of Seagram CEO Samuel Bronfman, heavily influenced the Seagram Building's design, an example of the functionalist aesthetic and a prominent instance of corporate modern architecture. A glass curtain wall with vertical mullions of bronze and horizontal spandrels made of Muntz metal form the building's exterior. The pink granite plaza facing Park Avenue contains two fountains. Behind the plaza is a tall elevator lobby with a similar design to the plaza. The lowest stories originally contained the Four Seasons and Brasserie restaurants, which were replaced respectively by the Grill and Pool restaurant and the Lobster Club. The upper stories contain office spaces of modular construction. Seagram revealed plans for the building in July 1954, when it announced construction of its headquarters on the up-and-coming commercial strip of Park Avenue. After Lambert objected to Pereira & Luckman's original design, Mies was selected as the architect that November. The building's construction began in late 1955 and finished in 1958, although the official certificate of occupancy was not granted until 1959. The Teachers Insurance and Annuity Association of America purchased the building in 1979, and it remained Seagram's headquarters until 2001. Since 2000, Aby Rosen's RFR Holding LLC has owned the Seagram Building. Upon opening, the Seagram Building was widely praised for its architecture. Described in The New York Times as one of "New York's most copied buildings", the Seagram Building has inspired the designs of other structures around the world. Within New York City, the Seagram Building helped influence the 1961 Zoning Resolution, a zoning ordinance that allowed developers to construct additional floor area in exchange for including plazas outside their buildings. In 1989, the New York City Landmarks Preservation Commission designated the Seagram Building's exterior, lobby, and The Four Seasons Restaurant as official city landmarks. The building was added to the National Register of Historic Places in 2006.

138 East 50th Street, officially named The Centrale, is a residential building in Midtown Manhattan, New York City. The building consists of 124 condominium residences and 7,500 square feet (700 m2) of ground-floor retail between Third Avenue and Lexington Avenue in Midtown East. The developers planned to sell the condominiums for a total of $535.7 million, or an average of $4.3 million per unit.

Selene (formerly known as 100 East 53rd Street and 610 Lexington Avenue) is a residential skyscraper at the southwest corner of 53rd Street and Lexington Avenue in Midtown Manhattan, New York City. The 64-story tower, completed in 2019, was designed by Norman Foster. At 711 feet (217 m) tall, it is the 64th tallest building in New York.

Le Jardinier is a restaurant in New York City. The restaurant has received a Michelin star.

The New York Marriott East Side was a hotel at 525 Lexington Avenue in Midtown Manhattan, New York City. It was built and opened in 1924 as the Shelton Towers Hotel. The hotel permanently closed in 2020 during the COVID-19 pandemic.